Fibrillin-3 expression in human development
نویسندگان
چکیده
منابع مشابه
Human eye development is characterized by coordinated expression of fibrillin isoforms.
PURPOSE Mutations in human fibrillin-1 and -2, which are major constituents of tissue microfibrils, can affect multiple ocular components, including the ciliary zonule, lens, drainage apparatus, cornea, and retina. However, the expression pattern of the three human fibrillins and an integral microfibrillar component, MAGP1, during human eye development is not known. METHODS We analyzed sectio...
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The human genome contains three fibrillins: FBN1 and FBN2, both well characterized, and FBN3, reported only as a cDNA sequence. Like FBN2, the highest expression levels of FBN3 were found in fetal tissues, with only low levels in postnatal tissues. Immunolocalization demonstrated fibrillin-3 in extracellular microfibrils abundant in developing skeletal elements, skin, lung, kidney, and skeletal...
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ژورنال
عنوان ژورنال: Matrix Biology
سال: 2011
ISSN: 0945-053X
DOI: 10.1016/j.matbio.2010.10.003